The laboratory of Professor Volker Haase studies hypoxia response pathways in erythropoiesis and iron metabolism, acute and chronic kidney injury, and tumorigenesis. A major focus of the lab is on the interplay between hypoxia signaling, metabolism and cellular differentiation and its regulation by the prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) / von Hippel-Lindau tumor suppressor (VHL) signaling axis. Haase group members take advantage of powerful cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study oxygen and mitochondrial metabolism in kidney, urologic and other diseases. Click on links for information about career opportunities in the Haase lab and publications.
Lab News and Updates
original research
Mitochondrial electron transport regulates aquaporin-2
Congratulations to Josh Carty, Ryoichi Bessho and team on the acceptance of their manuscript in JCI Insight. In this exciting study, we examine the role of oxidative phosphorylation in the regulation of body water homeostasis.
October 2024
Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin-2
announcement
Bessho receives the Sharon Anderson Research Fellowship Award from the American Society of Nephrology
June 2024
Congratulations to Dr. Ryoichi Bessho, M.D., Ph.D, for receiving the Sharon Anderson Research Fellowship Award as part of the Ben J. Lipps Research Program of the American Society of Nephrology (ASN). Ryoichi trained as an Endocrinologist at Asahikawa Medical University in Japan and joined the Haase lab in 2023. He studies the role of mitochondrial electron transport in kidney physiology and pathogenesis using genetic and single cell approaches. As a graduate student, he made seminal observations regarding the interplay between SGLT2 inhibition and hypoxic signaling in diabetic nephropathy.
announcement
Haase named Fellow of the American Association for the Advancement of Science
April 2024
This April, the American Association for the Advancement of Science (AAAS) announced that Volker H. Haase was elected Fellow of the AAAS for his distinguished contributions to the field of experimental and translational medicine, particularly for the development and use of mouse models to study mammalian oxygen sensing in health and disease. This is a great honor for the Haase lab and a reflection of the commitment and hard work of current and former group members.
Click this link to find out more about the seven Vanderbilt faculty members who were elected to the AAAS Fellow class of 2023. “At Vanderbilt, we’re thrilled to celebrate the election of our faculty members as AAAS fellows. It not only highlights our dedication to groundbreaking research and societal impact, but also showcases the inspiration they provide to future generations of scholars,” said C. Cybele Raver, provost and vice chancellor for academic affairs.