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Hypoxia Responses in Physiology and Pathogenesis

Changes in tissue oxygen levels occur under pathological conditions and physiologically during development. The laboratory of Volker Haase studies hypoxia response pathways and their therapeutic applications.

Volker Haase Lab

Oxygen logo Volker H Haase Laboratory

advancing HIF biology and HIF-based therapies

The laboratory of Professor Volker H. Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolismkidney injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis. A major focus of the lab is on the interplay between hypoxic signaling, metabolism and cellular differentiation and its regulation by the prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) / von Hippel-Lindau tumor suppressor (VHL) signaling axis. Haase group members take advantage of powerful cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study oxygen and mitochondrial metabolism in kidney, urologic and other diseases. Click on links for information about career opportunities in the Haase lab and recent publications.

Mitochondria renal epithelium

Mitochondria in renal epithelium

Epo RNA-FISH Volker Haase Lab

Erythropoietin-producing cells in the kidney
(red fluorescent signal)

Overwiew of oxygen metabolism in renal tissue

Mechanisms of Renal Hypoxia

Volker Haase Lab - HIF in fatty acid metabolism; Rankin MCB 2009

HIF activation in hepatocytes results in fatty livers

Haase Lab in 2017

research news and where you can meet us

In the Literature Editorial: ARNT as a novel target for anti-fibrotic therapy

September 2018

Per-Arnt-Sim (PAS) domain proteins are involved in the regulation of cellular responses to environmental stresses such as hypoxia and exposure to polycyclic aromatic hydrocarbons. In a new preclinical study, the research group of Michael Zeisberg at the University of Göttingen has identified the obligatory HIF-α binding partner ARNT as an anti-fibrotic and pro-regenerative inducer of activin-like kinase (ALK) 3 / SMAD signaling. The study suggests that ARNT has therapeutic potential for the treatment of chronic kidney disease (CKD). More …

Paper published on the clinical effects of HIF-PHI vadadustat in hemodialysis patients

April 2018

Erythropoiesis-stimulating agents (ESAs) can correct anemia in chronic kidney disease (CKD) but are associated with increased risks of cardiovascular events. Vadadustat, an inhibitor of hypoxia-inducible factor prolyl-4-hydroxylase domain (HIF-PHD) dioxygenases, is an oral investigational agent in development for the treatment of anemia in patients with CKD. In a 16-week, open-label, multicenter, Phase 2 trial, Haase and colleagues evaluated vadadustat in 94 patients receiving maintenance hemodialysis previously maintained on ESA therapy. More …

link to erythropoiesis, iron metabolism and renal anemia

link to media files on renal anemia

Haase lab identifies a new role for HIF-PHD oxygen sensors in kidney development

December 2017

Insufficient oxygenation during pregnancy negatively influences kidney development, which predisposes to chronic kidney disease at later stages in life. Kobayashi et al. demonstrate that deletion of HIF prolyl-hydroxylase (PHD) 2 and 3, in FoxD1 lineage cells reduces kidney size and inhibits nephrogenesis in mice. Temporospatial expression pattern and studies of additional knockout mice suggest the involvement of hypoxia-inducible factor (HIF)-2. More …

link to commentary in KI

link to research themes in the Haase lab

Meet Haase lab members at the 56th ERA-EDTA Congress in Budapest, Hungary

June 13-16, 2019

More information to follow soon.

Meet Haase lab members at the Annual AUA Meeting in Chicago, IL

May 3-6, 2019

More information to follow soon.