Hypoxia Responses in Physiology and Pathogenesis
Changes in tissue oxygen levels occur under pathological conditions and physiologically during development. The laboratory of Volker Haase studies hypoxia response pathways and their therapeutic applications.
Volker Haase Lab
advancing HIF biology and HIF-based therapies
The laboratory of Professor Volker H. Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolism, tissue injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis. The Haase lab has largely focused on the hypoxia-inducible factor (HIF) pathway, its regulation by prolyl hydroxylase domain (PHD) oxygen sensors and the von Hippel-Lindau (VHL) tumor suppressor. Haase group members take advantage of cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study the PHD/HIF pathway in the setting of acute and chronic kidney disease as well as other conditions. For career opportunities in the Haase lab click here, for recent publications from our group please click here.