The laboratory of Professor Volker Haase studies hypoxia response pathways in erythropoiesis and iron metabolism, acute and chronic kidney injury, and tumorigenesis. A major focus of the lab is on the interplay between hypoxia signaling, metabolism and cellular differentiation and its regulation by the prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) / von Hippel-Lindau tumor suppressor (VHL) signaling axis. Haase group members take advantage of powerful cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study oxygen and mitochondrial metabolism in kidney, urologic and other diseases. Click on links for information about career opportunities in the Haase lab and publications.
Lab News and Updates
educational resource
American Society of Hematology Educational Program: Update on HIF-PHI Therapy for Anemia in CKD
December 2024
Hypoxia-inducible factor activators: a novel class of oral drugs for the treatment of anemia of chronic kidney disease
original research
Mitochondrial electron transport regulates aquaporin-2
Congratulations to Josh Carty, Ryoichi Bessho and team on the acceptance of their manuscript in JCI Insight. In this exciting collaborative study between the Arroyo and Haase labs, we examine the role of oxidative phosphorylation in the regulation of body water homeostasis.
October 2024
Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin-2