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Hypoxia Responses in Physiology and Pathogenesis

Changes in tissue oxygen levels occur under pathological conditions and physiologically during development. The laboratory of Volker Haase studies hypoxia response pathways and their therapeutic applications.

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Volker Haase Lab

advancing HIF biology and HIF-based therapies

The laboratory of Professor Volker H. Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolismtissue injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis. The Haase lab has largely focused on the hypoxia-inducible factor (HIF) pathway, its regulation by prolyl hydroxylase domain (PHD) oxygen sensors and the von Hippel-Lindau (VHL) tumor suppressor. Haase group members take advantage of cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study the PHD/HIF pathway in the setting of acute and chronic kidney disease as well as other conditions. For career opportunities in the Haase lab click here, for recent publications from our group please click here.

Haase Lab in 2017
High resolution of imaging of mitochondria in renal epithelium

Mitochondria in renal epithelium

Epo RNA-FISH Volker Haase Lab

Erythropoietin-producing cells in the kidney
(red fluorescent signal)

Overwiew of oxygen metabolism in renal tissue

Mechanisms of Renal Hypoxia

Volker Haase Lab - HIF in fatty acid metabolism; Rankin MCB 2009

HIF activation in hepatocytes results in fatty livers

News

research news

click here to view pdf

 

Paper accepted on the clinical effects of HIF-PHI vadadustat in hemodialysis patients

February 2018

Effects of Vadadustat on Hemoglobin Concentrations in Patients Receiving Hemodialysis Previously Treated with Erythropoiesis Stimulating Agents

Congratulations to the authors:  Volker H. Haase, Glenn M. Chertow, Geoffrey A. Block, Pablo E. Pergola, Emil deGoma, Zeeshan Khawaja, Amit Sharma, Bradley J. Maroni and Peter A. McCullough.

Erythropoiesis-stimulating agents (ESAs) can correct anemia in chronic kidney disease (CKD) but are associated with increased risks of cardiovascular events. Vadadustat, an inhibitor of hypoxia-inducible factor prolyl-4-hydroxylase domain (HIF-PHD) dioxygenases, is an oral investigational agent in development for the treatment of anemia in patients with CKD. read more…

click here for a link to erythropoiesis, iron metabolism and renal anemia

click here for teaching on renal anemia

HIF-PHDs in renal development; Kobayashi et al., Kidney International 2017

(click for larger)

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commentary
in KI

Haase lab identifies a new role for HIF-PHD oxygen sensors in kidney development

December 2017

Insufficient oxygenation during pregnancy negatively influences kidney development, which predisposes to chronic kidney disease at later stages in life. Kobayashi et al. demonstrate that deletion of HIF prolyl-hydroxylase (PHD) 2 and 3, in FoxD1 lineage cells reduces kidney size and inhibits nephrogenesis in mice. Temporospatial expression pattern and studies of additional knockout mice suggest the involvement of hypoxia-inducible factor (HIF)-2. To view a pdf file of this paper click here.

link to research themes in the Haase lab

where you can meet us

Nanjing International Nephrology Forum & National CME Course, Chinese Society of Renal Physiology and Chinese Society of Nephrology, Nanjing, China

June 23, 2018

Volker Haase will discuss the role of oxygen sensing in renal physiology and pathogenesis.

Volker Haase will speak at the 63rd meeting of the Japanese Society for Dialysis Therapy (JSDT) in Kobe, Japan

June 29-July 1, 2018

Professor Haase will discuss HIF-PHD inhibition for the treatment of renal anemia.

for access to the meeting website click here

Fondation D.E.V.E.N.I.R (Démarches Visant à enrayer l’Émergence des conséquences Néfastes de l’Insuffisance Rénale), 5ème Forum Éducationnel pour les Néphrologues (F.E.N.), Ville de Québec, Canada

October 12-13, 2018

for program information please click here

Meet Haase Lab members at the American Society of Nephrology (ASN) annual meeting in San Diego, CA

October 25-28, 2018

More info regarding posters will follow soon.

Volker Haase to speak on “The Role of Interstitial Cell Oxygen Sensing in Nephrogenesis” in the educational session: “Old Cells in New Roles: Unusual Mechanisms in Kidney Remodeling”.

Meeting info to follow soon.