PEOPLE2018-11-20T14:47:18+00:00

Advancing HIF Biology and HIF-based Therapies

The laboratory of Professor Volker Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolismtissue injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis. A major focus of the lab is on the interplay between hypoxic signaling, metabolism and cellular differentiation and its regulation by the prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) / von Hippel-Lindau tumor suppressor (VHL) signaling axis. Haase group members take advantage of powerful cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study oxygen and mitochondrial metabolism in kidney, urologic and other diseases. Click on links for information about career opportunities in the Haase lab and recent publicationsWe represent a diverse and international group of researchers and students from multiple countries across the world.

Volker H. Haase, M.D.

Principal Investigator

Volker H. Haase, M.D., Dr. med.

Professor of Medicine and Professor of Molecular Physiology and Biophysics
The Krick-Brooks Chair in Nephrology

Volker Haase is a physician-scientist with clinical training in Internal Medicine and Nephrology and holds the Krick-Brooks Chair in Nephrology at Vanderbilt University. He is a leader in the field of mammalian oxygen sensing, prolyl hydroxylase domain oxygen sensor and HIF biology, and trained in experimental biology and genome editing under Professor Rudolf Jaenisch at the Whitehead InstituteProfessor Haase is the recipient of a Marie Curie/VINMER fellowship and the 2006 Sir William Osler Young Investigator award. He is an alumnus of the Studienstiftung des Deutschen Volkes and a member of the American Society for Clinical Investigation (ASCI). He was elected to the Association of American Physicians (AAP) in 2016. In addition to directing his research group, Professor Haase provides inpatient care in General Internal Medicine and Nephrology (see Clinical Activities in Internal Medicine and Nephrology).

Group Members

Aqeela Afzal, Ph.D.

Aqeela Afzal, Ph.D.

Research Assistant Professor

Aqeela Afzal received her Ph.D. in Pharmacology and an M.B.A from the University of Florida in Gainesville.  Aqeela works on mitochondrial metabolism in acute and chronic kidney injury and studies the role of HIF in blood brain barrier function and stroke.

Mikhael Burmakin, M.D., Ph.D.

Mikhail Burmakin, M.D., Ph.D.

Researcher

Mikhail Burmakin trained in Pediatric Nephrology and Molecular Biology.  Mikhail is interested in the effects of HIF prolyl hydroxylase domain enzyme inhibition on renal physiology and works with Volker Haase on single cell transcriptomic profiling for the study of kidney disease.

Douglass Clayton, MD, Assistant Professor of Pediatric Urology

Douglas B. Clayton, M.D.

Assistant Professor of Surgery

Doug Clayton is an Assistant Professor of Urologic Surgery and is a Pediatric Urologist. He is pursuing a career as a clinician scientist funded through a K08 Mentored Clinical Scientist Award. Doug’s research focus is on understanding hypoxia responses in bladder inflammation. When not seeing patients or working in the lab, Doug enjoys spending time with his wife and two young sons.

Olena Davidoff, M.S.

Lab Manager

Olena Davidoff received a Masters Degree in Molecular Diagnostics from Odessa University. Olena is interested in mouse genetics and animal work.

Nan Guan, M.D.

Visiting Graduate Student

Nan Guan received her M.D. degree (Bachelor of Medicine) from Fudan University in Shanghai, China.  She is the recipient of a China Scholarship Council fellowship and has joined the Haase laboratory to work on HIF and mitochondrial signaling in kidney disease as part of her Ph.D. studies.

Hanako Kobayashi, Ph.D.

Research Assistant Professor

Hanako Kobayashi received her Ph.D. in Molecular Nutrition Science from the University of California, Berkeley. Hanako studies the regulation of EPO in the kidney and is interested in the role of prolyl hydroxylase domain enzymes and HIF in the pathogenesis of acute and chronic kidney injury.

Carmen Tong, D.O.

Fellow in Pediatric Urology

Carmen Tong received her D.O. from the Arizona College of Osteopathic Medicine in Glendale, Arizona.  Carmen studies the role of mitochondria in polycystic kidney disease and diseases of the bladder.  She also manages the Haase lab social media account @HIFpathway.

Alumni

Rishab Kapoor, Ph.D.

click here for more info and present position

Andraia R. Li, B.S.

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 Shuvro De,  M.D.

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Ken Ishii, Pharm.D., Ph.D.

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Malini Rajan, Ph.D.

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Thomas C. Binns, B.S.

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Qingdu Liu, Ph.D.

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Xiaoqian Hu, Ph.D.

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Navid Farsijani, M.D.

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Hideto Sano, Ph.D.

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Travis Unger, M.S.

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Heather P. Shutt, B.S.N.

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Mangatt P. Biju, Ph.D.

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Yasuhiro Akai, M.D., Ph.D.

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Haase Lab Photographs

Volker Haase Lab 2018
Haase Lab Aug. 2018
Laboratory of Volker Haase studying hypoxia responses and hypoxia-inducible factor signaling in kidney disease and other pathologic conditions
Haase Lab Dec. 2017
Haase Lab 2015
Haase Lab Oct. 2015