PEOPLE 2018-05-14T21:24:48+00:00

Advancing HIF Biology and HIF-based Therapies

The laboratory of Professor Volker Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolismtissue injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis. The lab has largely focused on the hypoxia-inducible factor (HIF) pathway, its regulation by prolyl hydroxylase domain (PHD) oxygen sensors and the von Hippel-Lindau (VHL) tumor suppressor. Haase group members take advantage of cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study the PHD/HIF pathway in the setting of acute and chronic kidney disease as well as other conditions. For career opportunities in the Haase laboratory please click here, for recent publications from our group please click here.

Group Members

Volker H. Haase, M.D., Dr. med.

Professor of Medicine and Professor of Molecular Physiology and Biophysics
The Krick-Brooks Chair in Nephrology

Volker Haase is a physician-scientist with clinical training in Internal Medicine and Nephrology and holds the Krick-Brooks Chair in Nephrology at Vanderbilt University. He is a leader in the field of mammalian oxygen sensing and HIF biology, and trained in experimental biology and genome editing under Professor Rudolf Jaenisch at the Whitehead InstituteProfessor Haase is the recipient of the 2006 Sir William Osler Young Investigator award.  He is a member of the American Society for Clinical Investigation (ASCI) and was elected to the Association of American Physicians (AAP) in 2016.

Olena Davidoff, M.S.

Lab Manager

Olena Davidoff received a Masters Degree in Molecular Diagnostics from Odessa University. She is interested in mouse genetics and animal work.

Aqeela Afzal, Ph.D.

Research Assistant Professor

Aqeela Afzal received her Ph.D. in Pharmacology and an M.B.A from the University of Florida in Gainesville.  She works on mitochondrial metabolism in acute and chronic kidney injury and studies the role of HIF in blood brain barrier function and stroke.

Douglas B. Clayton, M.D.

Assistant Professor of Surgery

Doug Clayton is an Assistant Professor of Urologic Surgery and is a Pediatric Urologist. He is pursuing a career as a clinician scientist funded through a K08 Mentored Clinical Scientist Award. Doug’s research focus is on understanding hypoxia responses in bladder inflammation. When not seeing patients or working in the lab, Doug enjoys spending time with his wife and two young sons.

Rishab Kapoor, Ph.D.

Postdoctoral Fellow

Rishab Kapoor received his Ph.D. in Nephrology from Newcastle University, Newcastle upon Tyne, United Kingdom. He studies the role of mitochondria in renal disease progression and polycystic kidney disease.

Hanako Kobayashi, Ph.D.

Research Assistant Professor

Hanako Kobayashi received her Ph.D. in Molecular Nutrition Science from the University of California, Berkeley. She studies the regulation of EPO in the kidney and is interested in the role of HIF in the pathogenesis of acute and chronic kidney injury.

Mikhail Burmakin, M.D., Ph.D.

Researcher

Mikhail Burmakin trained in Pediatric Nephrology and Molecular Biology.  He is interested in the effects of HIF prolyl hydroxylase inhibition on renal physiology and works with Volker Haase on single cell transcriptomic profiling for the study of kidney disease.

Alumni

Ken Ishii, Pharm.D., Ph.D.

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Malini Rajan, Ph.D.

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Qingdu Liu, Ph.D.

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Xiaoqian Hu, Ph.D.

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Navid Farsijani, M.D.

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Hideto Sano, Ph.D.

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Travis Unger, M.S.

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Heather P. Shutt, B.S.N.

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Mangatt P. Biju, Ph.D.

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Yasuhiro Akai, M.D., Ph.D.

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