Ku E, Del Vecchio L, Eckardt KU, Haase VH, Johansen KL, Nangaku M, Tangri N, Waikar SS, Wiecek A, Cheung M, Jadoul M, Winkelmayer WC, Wheeler DC, . Novel anemia therapies in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int [print-electronic]. 2023 Oct; 104(4): 655-80. PMID: 37236424, PII: S0085-2538(23)00379-4, DOI: 10.1016/j.kint.2023.05.009.

Koury MJ, Haase VH. Deregulating iron-erythropoiesis regulation: transferrin receptor 2 as potential target for treating anemia in CKD. Kidney Int. 2023 Jul; 104(1): 25-8. PMID: 37349056, PII: S0085-2538(23)00334-4, DOI: 10.1016/j.kint.2023.04.017, ISSN: 1523-1755.

Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, Van Kaer L. Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Proc Natl Acad Sci U S A [print-electronic]. 2023 Jan 1/3/2023; 120(1): e2214874120. PMID: 36574710, PMCID: PMC9910429, DOI: 10.1073/pnas.2214874120, ISSN: 1091-6490.

Li J, Haase VH, Hao CM. Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia. Kidney Dis (Basel). 2023 Jan; 9(1): 1-11. PMID: 36756084, PMCID: PMC9900466, PII: kdd-0009-0001, DOI: 10.1159/000527835, ISSN: 2296-9381.

Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH. Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int [print-electronic]. 2022 Jul; 102(1): 108-20. PMID: 35341793, PII: S0085-2538(22)00212-5, DOI: 10.1016/j.kint.2022.02.030, ISSN: 1523-1755.

Clayton DB, Tong CMC, Li B, Taylor AS, De S, Mason MD, Dudley AG, Davidoff O, Kobayashi H, Haase VH. Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction. Am J Physiol Renal Physiol [print-electronic]. 2022 Jul 7/1/2022; 323(1): F81-F91. PMID: 35499237, DOI: 10.1152/ajprenal.00344.2021, ISSN: 1522-1466.

Koury MJ, Agarwal R, Chertow GM, Eckardt KU, Fishbane S, Ganz T, Haase VH, Hanudel MR, Parfrey PS, Pergola PE, Roy-Chaudhury P, Tumlin JA, Anders R, Farag YMK, Luo W, Minga T, Solinsky C, Vargo DL, Winkelmayer WC. Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease. Am J Hematol [print-electronic]. 2022 Jun 6/25/2022; PMID: 35751858, DOI: 10.1002/ajh.26644, ISSN: 1096-8652.

Kobayashi H, Davidoff O, Pujari-Palmer S, Drevin M, Haase VH. EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis. Acta Physiol (Oxf) [print-electronic]. 2022 May 5/1/2022; e13826. PMID: 35491502, DOI: 10.1111/apha.13826, ISSN: 1748-1716.

Haase VH. The ins and outs of ferric citrate. Kidney Int. 2022 Apr; 101(4): 668-70. PMID: 35314048, PII: S0085-2538(22)00065-5, DOI: 10.1016/j.kint.2021.12.032, ISSN: 1523-1755.

Burmakin M, Fasching A, Kobayashi H, Urrutia AA, Damdimopoulos A, Palm F, Haase VH. Pharmacological HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation. Acta Physiol (Oxf) [print-electronic]. 2021 Sep; 233(1): e13668. PMID: 33900001, DOI: 10.1111/apha.13668, ISSN: 1748-1716.

Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Malyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB, . Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int [print-electronic]. 2021 Jun; 99(6): 1280-95. PMID: 33839163, PII: S0085-2538(21)00355-0, DOI: 10.1016/j.kint.2021.03.020.

Boothby MR, Raybuck A, Cho SH, Stengel KR, Haase VH, Hiebert S, Li J. Over-Generalizing About GC (Hypoxia): Pitfalls of Limiting Breadth of Experimental Systems and Analyses in Framing Informatics Conclusions. Front Immunol. 2021 May 5/10/2021; 12: 664249. PMID: 34040610, PMCID: PMC8141812, DOI: 10.3389/fimmu.2021.664249, ISSN: 1664-3224.

Haase VH. Hypoxia-inducible factor-prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease. Kidney Int Suppl (2011) [print-electronic]. 2021 Apr; 11(1): 8-25. PMID: 33777492, PMCID: PMC7983025, PII: S2157-1716(21)00002-2, DOI: 10.1016/j.kisu.2020.12.002, ISSN: 2157-1724.

Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH. Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease. Kidney Int [print-electronic]. 2020 Nov 11/4/2020; PMID: 33159962, PII: S0085-2538(20)31250-3, DOI: 10.1016/j.kint.2020.10.013, ISSN: 1523-1755.

Zou J, Yang J, Zhu X, Zhong J, Elshaer A, Matsusaka T, Pastan I, Haase VH, Yang HC, Fogo AB. Stabilization of Hypoxia-Inducible Factor Ameliorates Glomerular Injury Sensitization after Tubulointerstitial Injury. Kidney Int [print-electronic]. 2020 Oct 10/30/2020; PMID: 33137336, PII: S0085-2538(20)31240-0, DOI: 10.1016/j.kint.2020.09.031, ISSN: 1523-1755.

Urrutia AA, Guan N, Mesa-Ciller C, Afzal A, Davidoff O, Haase VH. Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin. Acta Physiol (Oxf) [print-electronic]. 2020 Aug 8/26/2020; e13547. PMID: 32846048, DOI: 10.1111/apha.13547, ISSN: 1748-1716.

Haase VH. Got glycogen? An energy resource in HIF-mediated prevention of ischemic kidney injury. Kidney Int. 2020 Apr; 97(4): 645-7. PMID: 32200856, PII: S0085-2538(20)30011-9, DOI: 10.1016/j.kint.2019.11.036, ISSN: 1523-1755.

Sanghani NS, Haase VH. Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience. Adv Chronic Kidney Dis. 2019 Jul;26(4):253-66. PMID: 31477256, PII: S1548-5595(19)30092-8, DOI: 10.1053/j.ackd.2019.04.004, ISSN: 1548-5609.

Cho SH, Raybuck AL, Blagih J, Kemboi E, Haase VH, Jones RG, Boothby MR. Hypoxia-inducible factors in CD4⁺ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity. Proc Natl Acad Sci USA. 2019 Apr 30;116(18):8975-84; PMID: 30988188, PII: 1811702116, DOI: 10.1073/pnas.1811702116, ISSN: 1091-6490.

Buell KG, Trumbo SP, Haase VH. Diagnostic Dilemma: A Unilateral Facial Rash with Eye Involvement. Am J Med. 2019 Jul;132(7):823-25; PMID: 30849384, PII: S0002-9343(19)30169-X, DOI: 10.1016/j.amjmed.2019.02.007, ISSN: 1555-7162.

Haase VH. ARNT as a novel anti-fibrotic target in chronic kidney disease. Am J Kidney Dis. 2019 Feb;73(2):281-284. Epub 2018 Oct, no abstract available; PPMID: 30343956, PMCID: PMC6348016, PII: S0272-6386(18)30912-0, DOI: 10.1053/j.ajkd.2018.08.009, ISSN: 1523-6838.

Haase VH, Chertow GM, Block GA, Pergola PE, deGoma EM, Khawaja Z, Sharma A, Maroni BJ, McCullough PA. Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents. Nephrol Dial Transplant. 2019 Jan 1;34(1):90-9; Epub 2018 Apr; PMID: 29672740, PMCID: PMC6322440, PII: 4973359, DOI: 10.1093/ndt/gfy055, ISSN: 1460-2385.

Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH. Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec; 92(6): 1370-83. PMID: 28847650, DOI: 10.1016/j.kint.2017.06.015, ISSN: 1523-1755. See editorial comment in the same issue of Kidney International on page 1314.

Haase VH. HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism. Hemodial Int. 2017 Jun; 21 Suppl 1: S110-S124. PMID: 28449418, DOI: 10.1111/hdi.12567, ISSN: 1542-4758.

Stenvinkel P, Haase VH. Inflamed fat and mitochondrial dysfunction in end-stage renal disease links to hypoxia-could curcumin be of benefit? [editorial]. Nephrol. Dial. Transplant. 2017 Jun 6/1/2017; 32(6): 909-12. PMID: 28460128, PII: 3782571, DOI: 10.1093/ndt/gfx052, ISSN: 1460-2385.

Haase VH. Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies. Exp. Cell Res [print-electronic]. 2017 May 5/5/2017; PMID: 28483447, DOI: 10.1016/j.yexcr.2017.05.004, ISSN: 1090-2422.

Haase VH. Oxygen sensors as therapeutic targets in kidney disease. Nephrol. Ther. 2017 Apr; 13 Suppl 1: S29-S34. PMID: 28577740, DOI: 10.1016/j.nephro.2017.01.015, ISSN: 1872-9177.

Urrutia AA, Afzal A, Nelson J, Davidoff O, Gross KW, Haase VH. Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes. Blood. 2016 Nov 11/24/2016; 128(21): 2550-60. PMID: 27683416, PII: blood-2016-05-713545, DOI: 10.1182/blood-2016-05-713545, ISSN: 1528-0020. See associated commentary in the same issue of Blood: “Pericytes: new EPO-producing cells in the brain”.

Pergola PE, Spinowitz BS, Hartman CS, Maroni BJ, Haase VH. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int [print-electronic]. 2016 Nov; 90(5): 1115-22. PMID: 27650732, PII: S0085-2538(16)30357-X, DOI: 10.1016/j.kint.2016.07.019, ISSN: 1523-1755.

Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature [print-electronic]. 2016 Aug 8/8/2016; PMID: 27501247, PII: nature19334, DOI: 10.1038/nature19334, ISSN: 1476-4687.

Kapitsinou PP, Rajendran G, Astleford L, Michael M, Schonfeld MP, Fields T, Shay S, French JL, West J, Haase VH. The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice. Mol Cell Biol [electronic-print]. 2016 May 5/15/2016; 36(10): 1584-94. PMID: 26976644, PII: MCB.01055-15, DOI: 10.1128/MCB.01055-15, ISSN: 1098-5549.

Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest [print-electronic]. 2016 May 5/2/2016; 126(5): 1926-38. PMID: 27088801, PII: 83551, DOI: 10.1172/JCI83551, ISSN: 1558-8238.

Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O’Connor PM, Haase VH. Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest [print-electronic]. 2016 Apr 4/1/2016; 126(4): 1425-37. PMID: 26927670, PMCID: PMC4811147, PII: 74997, DOI: 10.1172/JCI74997, ISSN: 1558-8238.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.

Kapitsinou PP, Haase VH. Molecular mechanisms of ischemic preconditioning in the kidney. Am J Physiol Renal Physiol [print-electronic]. 2015 Nov 11/15/2015; 309(10): F821-34. PMID: 26311114, PII: ajprenal.00224.2015, DOI: 10.1152/ajprenal.00224.2015, ISSN: 1522-1466.

Haase VH. Inflammation and hypoxia in the kidney: friends or foes?. Kidney Int. 2015 Aug; 88(2): 213-5. PMID: 26230196, PMCID: PMC4534718, PII: ki201589, DOI: 10.1038/ki.2015.89, ISSN: 1523-1755.

Koury MJ, Haase VH. Anaemia in kidney disease: harnessing hypoxia responses for therapy. Nat Rev Nephrol [print-electronic]. 2015 Jul; 11(7): 394-410. PMID: 26055355, PMCID: PMC4497972, PII: nrneph.2015.82, DOI: 10.1038/nrneph.2015.82, ISSN: 1759-507X.

Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol [print-electronic]. 2015 Jun 6/15/2015; 308(12): F1452-62. PMID: 25925251, PMCID: PMC4469889, PII: ajprenal.00066.2015, DOI: 10.1152/ajprenal.00066.2015, ISSN: 1522-1466.

Haase VH. A breath of fresh air for diabetic nephropathy [editorial]. J Am Soc Nephrol [print-electronic]. 2015 Feb; 26(2): 239-41. PMID: 25183808, PMCID: PMC4310668, PII: ASN.2014080754, DOI: 10.1681/ASN.2014080754, ISSN: 1533-3450.

Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest [print-electronic]. 2014 Jun; 124(6): 2396-409. PMID: 24789906, PMCID: PMC4092875, PII: 69073, DOI: 10.1172/JCI69073, ISSN: 1558-8238.

Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J. Am Soc Nephrol [print-electronic]. 2014 Mar; 25(3): 547-63. PMID: 24262796, PMCID: PMC3935577, PII: ASN.2012101014, DOI: 10.1681/ASN.2012101014, ISSN: 1533-3450.

Haase VH. Mechanisms of hypoxia responses in renal tissue. J Am Soc Nephrol [print-electronic]. 2013 Mar; 24(4): 537-41. PMID: 23334390, PII: ASN.2012080855, DOI: 10.1681/ASN.2012080855, ISSN: 1533-3450.

Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev [print-electronic]. 2013 Jan; 27(1): 41-53. PMID: 23291219, PMCID: PMC3731139, PII: S0268-960X(12)00084-7, DOI: 10.1016/j.blre.2012.12.003, ISSN: 1532-1681.

Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Celeste Simon M, Giordano FJ, Yun Z. Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc. 2013; 2(6): e000548. PMID: 24326162, PMCID: PMC3886757, PII: jah3381, DOI: 10.1161/JAHA.113.000548, ISSN: 2047-9980.

Liu Q, Davidoff O, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J. Clin. Invest [print-electronic]. 2012 Dec; 122(12): 4635-44. PMID: 23114598, PMCID: PMC3533545, PII: 63924, DOI: 10.1172/JCI63924, ISSN: 1558-8238.

Park SW, Kim M, Kim JY, Brown KM, Haase VH, D’Agati VD, Lee HT. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int [print-electronic]. 2012 Oct; 82(8): 878-91. PMID: 22695326, PMCID: PMC3443517, PII: ki2012224, DOI: 10.1038/ki.2012.224, ISSN: 1523-1755.

Kobayashi H, Gilbert V, Liu Q, Kapitsinou PP, Unger TL, Rha J, Rivella S, Schlöndorff D, Haase VH. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J. Immunol [print-electronic]. 2012 May 5/15/2012; 188(10): 5106-15. PMID: 22490864, PMCID: PMC3345098, PII: jimmunol.1103377, DOI: 10.4049/jimmunol.1103377, ISSN: 1550-6606.

Haase VH. Renal cancer: oxygen meets metabolism. Exp. Cell Res [print-electronic]. 2012 May 5/15/2012; 318(9): 1057-67. PMID: 22406000, PMCID: PMC3334413, PII: S0014-4827(12)00102-4, DOI: 10.1016/j.yexcr.2012.02.026, ISSN: 1090-2422.

Kapitsinou PP, Jaffe J, Michael M, Swan CE, Duffy KJ, Erickson-Miller CL, Haase VH. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2012 May 5/1/2012; 302(9): F1172-9. PMID: 22262480, PMCID: PMC3362175, PII: ajprenal.00667.2011, DOI: 10.1152/ajprenal.00667.2011, ISSN: 1522-1466.

Haase VH. Hypoxia-inducible factor signaling in the development of kidney fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1): S16. PMID: 23259746, PMCID: PMC3368791, PII: 1755-1536-5-S1-S16, DOI: 10.1186/1755-1536-5-S1-S16, ISSN: 1755-1536.

Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 4/6/2011; 13(4): 469-75. PMID: 21459331, PMCID: PMC3070917, PII: S1550-4131(11)00088-X, DOI: 10.1016/j.cmet.2011.03.001, ISSN: 1932-7420.

Haase VH. Angiotensin II: breathtaking in the renal medulla. Kidney Int. 2011 Feb; 79(3): 269-71. PMID: 21228800, PMCID: PMC3621768, PII: ki2010434, DOI: 10.1038/ki.2010.434, ISSN: 1523-1755.

Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J. Clin. Invest [print-electronic]. 2010 Nov; 120(11): 4040-54. PMID: 20978353, PMCID: PMC2964979, PII: 43025, DOI: 10.1172/JCI43025, ISSN: 1558-8238.

Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood [print-electronic]. 2010 Oct 10/21/2010; 116(16): 3039-48. PMID: 20628150, PMCID: PMC2974609, PII: blood-2010-02-270322, DOI: 10.1182/blood-2010-02-270322, ISSN: 1528-0020.

Hao CM, Haase VH. Sirtuins and their relevance to the kidney. J. Am. Soc. Nephrol [print-electronic]. 2010 Oct; 21(10): 1620-7. PMID: 20595677, PMCID: PMC4527176, PII: ASN.2010010046, DOI: 10.1681/ASN.2010010046, ISSN: 1533-3450.

Kapitsinou PP, Haase VH. HO-1 in control of a self-eating kidney [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2010 Oct; 21(10): 1600-2. PMID: 20829407, PMCID: PMC4530623, PII: ASN.2010080876, DOI: 10.1681/ASN.2010080876, ISSN: 1533-3450.

Welford SM, Dorie MJ, Li X, Haase VH, Giaccia AJ. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol. Cell. Biol [print-electronic]. 2010 Oct; 30(19): 4595-603. PMID: 20679489, PMCID: PMC2950534, PII: MCB.01618-09, DOI: 10.1128/MCB.01618-09, ISSN: 1098-5549.

Weidemann A, Krohne TU, Aguilar E, Kurihara T, Takeda N, Dorrell MI, Simon MC, Haase VH, Friedlander M, Johnson RS. Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia. 2010 Aug; 58(10): 1177-85. PMID: 20544853, PMCID: PMC2993327, DOI: 10.1002/glia.20997, ISSN: 1098-1136.

Haase VH. The sweet side of HIF. Kidney Int. 2010 Jul; 78(1): 10-3. PMID: 20551925, PMCID: PMC3789845, PII: ki2010112, DOI: 10.1038/ki.2010.112, ISSN: 1523-1755.

Haase VH. Hypoxic regulation of erythropoiesis and iron metabolism. Am. J. Physiol. Renal Physiol [print-electronic]. 2010 Jul; 299(1): F1-13. PMID: 20444740, PMCID: PMC2904169, PII: ajprenal.00174.2010, DOI: 10.1152/ajprenal.00174.2010, ISSN: 1522-1466.

Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J. Am. Soc. Nephrol [print-electronic]. 2010 Jun; 21(6): 955-65. PMID: 20338995, PMCID: PMC2900956, PII: ASN.2009060662, DOI: 10.1681/ASN.2009060662, ISSN: 1533-3450.

Wei Q, Bhatt K, He HZ, Mi QS, Haase VH, Dong Z. Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J. Am. Soc. Nephrol [print-electronic]. 2010 May; 21(5): 756-61. PMID: 20360310, PMCID: PMC2865746, PII: ASN.2009070718, DOI: 10.1681/ASN.2009070718, ISSN: 1533-3450.

Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS. VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am. J. Pathol [print-electronic]. 2010 May; 176(5): 2269-82. PMID: 20382704, PMCID: PMC2861092, PII: S0002-9440(10)60023-5, DOI: 10.2353/ajpath.2010.090310, ISSN: 1525-2191.

Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis [print-electronic]. 2010 Mar; 31(3): 427-34. PMID: 20042640, PMCID: PMC2832548, PII: bgp326, DOI: 10.1093/carcin/bgp326, ISSN: 1460-2180.

Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J. Clin. Invest [print-electronic]. 2009 Nov; 119(11): 3373-83. PMID: 19809162, PMCID: PMC2769183, PII: 39378, DOI: 10.1172/JCI39378, ISSN: 1558-8238.

Haase VH. Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis. Ann. N. Y. Acad. Sci. 2009 Oct; 1177: 57-65. PMID: 19845607, PMCID: PMC4529330, PII: NYAS5030, DOI: 10.1111/j.1749-6632.2009.05030.x, ISSN: 1749-6632.

Haase VH. Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int [print-electronic]. 2009 Sep; 76(5): 492-9. PMID: 19536078, PMCID: PMC3623274, PII: ki2009222, DOI: 10.1038/ki.2009.222, ISSN: 1523-1755.

Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH. Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol. Cell. Biol [print-electronic]. 2009 Aug; 29(16): 4527-38. PMID: 19528226, PMCID: PMC2725738, PII: MCB.00200-09, DOI: 10.1128/MCB.00200-09, ISSN: 1098-5549.

Haase VH. The VHL tumor suppressor: master regulator of HIF. Curr. Pharm. Des. 2009; 15(33): 3895-903. PMID: 19671042, PMCID: PMC3622710, PII: CPD-Volker H. Haase (Kietzman), ISSN: 1873-4286.

Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, Haase VH, Saito Y. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am. J. Physiol. Renal Physiol [print-electronic]. 2008 Oct; 295(4): F1023-9. PMID: 18667485, PMCID: PMC4250235, PII: 90209.2008, DOI: 10.1152/ajprenal.90209.2008, ISSN: 1931-857X.

Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene [print-electronic]. 2008 Sep 9/11/2008; 27(40): 5354-8. PMID: 18490920, PMCID: PMC2575082, PII: onc2008160, DOI: 10.1038/onc.2008.160, ISSN: 1476-5594.

Haase VH. Hemoglobin in the kidney: breaking with traditional dogma [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2008 Aug; 19(8): 1440-1. PMID: 18614770, PII: ASN.2008060594, DOI: 10.1681/ASN.2008060594, ISSN: 1533-3450.

Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology [print-electronic]. 2008 Jun; 134(7): 2036-48, 2048.e1. PMID: 18439915, PMCID: PMC2533811, PII: S0016-5085(08)00440-X, DOI: 10.1053/j.gastro.2008.03.009, ISSN: 1528-0012.

Higgins DF, Kimura K, Iwano M, Haase VH. Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle [print-electronic]. 2008 May 5/1/2008; 7(9): 1128-32. PMID: 18418042, PMCID: PMC3784650, PII: 5804, ISSN: 1551-4005.

Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 4/18/2008; 133(2): 223-34. PMID: 18423195, PMCID: PMC2849644, PII: S0092-8674(08)00289-4, DOI: 10.1016/j.cell.2008.02.038, ISSN: 1097-4172.

Maltzman JS, Haase VH. Low oxygen stimulates the immune system. Kidney Int. 2008 Apr; 73(7): 797-9. PMID: 18340350, PMCID: PMC3791324, PII: ki200815, DOI: 10.1038/ki.2008.15, ISSN: 1523-1755.

Peng M, Falk MJ, Haase VH, King R, Polyak E, Selak M, Yudkoff M, Hancock WW, Meade R, Saiki R, Lunceford AL, Clarke CF, Gasser DL. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet. 2008 Apr; 4(4): e1000061. PMID: 18437205, PMCID: PMC2291193, DOI: 10.1371/journal.pgen.1000061, ISSN: 1553-7404.

Kapitsinou PP, Haase VH. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ [print-electronic]. 2008 Apr; 15(4): 650-9. PMID: 18219317, PMCID: PMC3799983, PII: 4402313, DOI: 10.1038/sj.cdd.4402313, ISSN: 1350-9047.

Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J. Clin. Invest. 2007 Dec; 117(12): 3810-20. PMID: 18037992, PMCID: PMC2082142, DOI: 10.1172/JCI30487, ISSN: 0021-9738.

Brukamp K, Jim B, Moeller MJ, Haase VH. Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. Am. J. Physiol. Renal Physiol [print-electronic]. 2007 Oct; 293(4): F1397-407. PMID: 17609290, PII: 00133.2007, DOI: 10.1152/ajprenal.00133.2007, ISSN: 1931-857X.

Blouw B, Haase VH, Song H, Bergers G, Johnson RS. Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene [print-electronic]. 2007 Jul 7/5/2007; 26(31): 4531-40. PMID: 17297464, PII: 1210249, DOI: 10.1038/sj.onc.1210249, ISSN: 0950-9232.

Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J. Clin. Invest. 2007 Jul; 117(7): 1926-32. PMID: 17557118, PMCID: PMC1884690, DOI: 10.1172/JCI31370, ISSN: 0021-9738.

Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J. Clin. Invest. 2007 Jun; 117(6): 1616-26. PMID: 17549257, PMCID: PMC1878533, DOI: 10.1172/JCI31581, ISSN: 0021-9738.

Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J. Clin. Invest. 2007 Apr; 117(4): 1068-77. PMID: 17404621, PMCID: PMC1838939, DOI: 10.1172/JCI30117, ISSN: 0021-9738.

Park SK, Haase VH, Johnson RS. Von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int. J. Oncol. 2007 Feb; 30(2): 341-8. PMID: 17203215, ISSN: 1019-6439.

Ding M, Cui S, Li C, Jothy S, Haase V, Steer BM, Marsden PA, Pippin J, Shankland S, Rastaldi MP, Cohen CD, Kretzler M, Quaggin SE. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat. Med [print-electronic]. 2006 Sep; 12(9): 1081-7. PMID: 16906157, PII: nm1460, DOI: 10.1038/nm1460, ISSN: 1078-8956.

Haase VH. Hypoxia-inducible factors in the kidney. Am. J. Physiol. Renal Physiol [print-electronic]. 2006 Aug; 291(2): F271-81. PMID: 16554418, PMCID: PMC4232221, PII: 00071.2006, DOI: 10.1152/ajprenal.00071.2006, ISSN: 1931-857X.

Wang J, Biju MP, Wang MH, Haase VH, Dong Z. Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J. Am. Soc. Nephrol [print-electronic]. 2006 Jul; 17(7): 1875-85. PMID: 16762987, PII: ASN.2005121371, DOI: 10.1681/ASN.2005121371, ISSN: 1046-6673.

Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood [print-electronic]. 2006 Jul 7/1/2006; 108(1): 123-33. PMID: 16527892, PMCID: PMC1895827, PII: 2005-11-4458, DOI: 10.1182/blood-2005-11-4458, ISSN: 0006-4971.

Tang N, Mack F, Haase VH, Simon MC, Johnson RS. PVHL function is essential for endothelial extracellular matrix deposition. Mol. Cell. Biol. 2006 Apr; 26(7): 2519-30. PMID: 16537898, PMCID: PMC1430327, PII: 26/7/2519, DOI: 10.1128/MCB.26.7.2519-2530.2006, ISSN: 0270-7306.

Haase VH. The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease. Kidney Int. 2006 Apr; 69(8): 1302-7. PMID: 16531988, PII: 5000221, DOI: 10.1038/sj.ki.5000221, ISSN: 0085-2538.

Rankin EB, Tomaszewski JE, Haase VH. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006 Mar 3/1/2006; 66(5): 2576-83. PMID: 16510575, PMCID: PMC3514875, PII: 66/5/2576, DOI: 10.1158/0008-5472.CAN-05-3241, ISSN: 0008-5472.

Biju MP, Akai Y, Shrimanker N, Haase VH. Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent. Am. J. Physiol. Renal Physiol [print-electronic]. 2005 Dec; 289(6): F1217-26. PMID: 16048903, PII: 00233.2005, DOI: 10.1152/ajprenal.00233.2005, ISSN: 1931-857X.

Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Nov 11/22/2005; 102(47): 17071-6. PMID: 16286658, PMCID: PMC1287984, PII: 0506070102, DOI: 10.1073/pnas.0506070102, ISSN: 0027-8424.

Haase VH. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin. Cell Dev. Biol [print-electronic]. 2005 Aug; 16(4-5): 564-74. PMID: 15908240, PMCID: PMC3787877, PII: S1084-9521(05)00052-2, DOI: 10.1016/j.semcdb.2005.03.006, ISSN: 1084-9521.

Mack FA, Patel JH, Biju MP, Haase VH, Simon MC. Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol. Cell. Biol. 2005 Jun; 25(11): 4565-78. PMID: 15899860, PMCID: PMC1140627, PII: 25/11/4565, DOI: 10.1128/MCB.25.11.4565-4578.2005, ISSN: 0270-7306.

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol. Cell. Biol. 2005 Apr; 25(8): 3163-72. PMID: 15798202, PMCID: PMC1069599, PII: 25/8/3163, DOI: 10.1128/MCB.25.8.3163-3172.2005, ISSN: 0270-7306.

Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle [print-electronic]. 2005 Feb; 4(2): 256-8. PMID: 15655360, PII: 1407, ISSN: 1551-4005.

Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. Hypoxic induction of Ctgf is directly mediated by Hif-1. Am. J. Physiol. Renal Physiol [print-electronic]. 2004 Dec; 287(6): F1223-32. PMID: 15315937, PII: 00245.2004, DOI: 10.1152/ajprenal.00245.2004, ISSN: 1931-857X.

Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 2004 Oct; 114(8): 1098-106. PMID: 15489957, PMCID: PMC522241, DOI: 10.1172/JCI21086, ISSN: 0021-9738.

Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 2004 Oct; 24(20): 9038-47. PMID: 15456877, PMCID: PMC517905, PII: 24/20/9038, DOI: 10.1128/MCB.24.20.9038-9047.2004, ISSN: 0270-7306.

Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004 May; 131(10): 2497-508. PMID: 15128677, PII: 131/10/2497, DOI: 10.1242/dev.01138, ISSN: 0950-1991.

Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR. DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Kidney Int. 2003 Dec; 64(6): 2079-91. PMID: 14633130, DOI: 10.1046/j.1523-1755.2003.00306.x, ISSN: 0085-2538.

Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 2003 Jul; 23(14): 4959-71. PMID: 12832481, PMCID: PMC162224, ISSN: 0270-7306.

Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 3/7/2003; 112(5): 645-57. PMID: 12628185, PMCID: PMC4480774, PII: S0092867403001545, ISSN: 0092-8674.

Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001 Dec 12/1/2001; 98(12): 3261-73. PMID: 11719363, ISSN: 0006-4971.

Haase VH, Glickman JN, Socolovsky M, Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2001 Feb 2/13/2001; 98(4): 1583-8. PMID: 11171994, PMCID: PMC29300, PII: 98/4/1583, DOI: 10.1073/pnas.98.4.1583, ISSN: 0027-8424.

Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A. A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin. J. Biol. Chem. 1997 Jan 1/10/1997; 272(2): 1297-301. PMID: 8995435, ISSN: 0021-9258.

Haase VH, Schmidt EV, Wang T, Bernards A. Normal lymphopoiesis in transgenic mice overexpressing the ltk transmembrane tyrosine kinase. Transgenics. 1995; ((1)): 487-95.

Haase VH, Trofatter JA, MacCollin M, Tarttelin E, Gusella JF, Ramesh V. The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms. Hum. Mol. Genet. 1994 Mar; 3(3): 407-11. PMID: 8012352, ISSN: 0964-6906.

Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K, Haase VH, et al. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell. 1993 Nov 11/19/1993; 75(4): 826. PMID: 8242753, PII: 0092-8674(93)90501-G, ISSN: 0092-8674.

Snijders AJ, Haase VH, Bernards A. Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment. Oncogene. 1993 Jan; 8(1): 27-35. PMID: 8380920, ISSN: 0950-9232.

Bernards A, Haase VH, Murthy AE, Menon A, Hannigan GE, Gusella JF. Complete human NF1 cDNA sequence: two alternatively spliced mRNAs and absence of expression in a neuroblastoma line. DNA Cell Biol. 1992 Dec; 11(10): 727-34. PMID: 1457041, ISSN: 1044-5498.

Haase VH, Snijders AJ, Cooke SM, Teng MN, Kaul D, Le Beau MM, Bruns GA, Bernards A. Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain. Oncogene. 1991 Dec; 6(12): 2319-25. PMID: 1662793, ISSN: 0950-9232.

Burmakin M, Fasching A, Kobayashi H, Urrutia AA, Damdimopoulos A, Palm F, Haase VH. Pharmacologic HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation. Acta Physiol (Oxf) [print-electronic]. 2021 Apr 4/26/2021; e13668. PMID: 33900001, DOI: 10.1111/apha.13668, ISSN: 1748-1716.
commentary: Get used to the -dustats: Roxadustat and molidustat, members of the hypoxia-inducible factor (HIF) Prolyl hydroxylase (PHD) inhibitor drug class promote kidney function, perfusion and oxygenation in rats through nitric oxide [Acta Physiologica 2021].

Urrutia AA, Guan N, Mesa-Ciller C, Afzal A, Davidoff O, Haase VH. Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin. Acta Physiol (Oxf) [print-electronic]. 2020 Aug 8/26/2020; e13547. PMID: 32846048, DOI: 10.1111/apha.13547, ISSN: 1748-1716.
commentary:

(click on image to view file)

Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH. Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec; 92(6): 1370-83. PMID: 28847650, PII: S0085-2538(17)30475-1, DOI: 10.1016/j.kint.2017.06.015, ISSN: 1523-1755.
commentary: PHD in the FOXD1 lineage cells links hypoxia to inappropriate nephrogenesis. [Kidney Int 2017]

Urrutia AA, Afzal A, Nelson J, Davidoff O, Gross KW, Haase VH. Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes. Blood. 2016 Nov 11/24/2016; 128(21): 2550-60. PMID: 27683416, PII: blood-2016-05-713545, DOI: 10.1182/blood-2016-05-713545, ISSN: 1528-0020.
commentary: : Pericytes: new EPO-producing cells in the brain. [Blood 2016]

Kobayashi H, Gilbert V, Liu Q, Kapitsinou PP, Unger TL, Rha J, Rivella S, Schlöndorff D, Haase VH. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J. Immunol [print-electronic]. 2012 May 5/15/2012; 188(10): 5106-15. PMID: 22490864, PMCID: PMC3345098, PII: jimmunol.1103377, DOI: 10.4049/jimmunol.1103377, ISSN: 1550-6606
commentary:

(click on image to view file)

Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J. Clin. Invest. 2007 Apr; 117(4): 1068-77. PMID: 17404621, PMCID: PMC1838939, DOI: 10.1172/JCI30117, ISSN: 0021-9738.
commentary: HIF-1 and HIF-2: working alone or together in hypoxia? [JCI 2007]

Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH. Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol. Cell. Biol [print-electronic]. 2009 Aug; 29(16): 4527-38. PMID: 19528226, PMCID: PMC2725738, PII: MCB.00200-09, DOI: 10.1128/MCB.00200-09, ISSN: 1098-5549.
commentary:

(click on cover to link to media file)

Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene [print-electronic]. 2008 Sep 9/11/2008; 27(40): 5354-8. PMID: 18490920, PMCID: PMC2575082, PII: onc2008160, DOI: 10.1038/onc.2008.160, ISSN: 1476-5594.
commentary:

(click on image to view file)