Haase Lab Publications

Changes in tissue oxygen levels occur under pathological conditions and physiologically during development. The laboratory of Professor Volker H. Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolismtissue injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis.

A major focus of the lab is on the interplay between hypoxic signaling, metabolism and cellular differentiation and its regulation by the prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) / von Hippel-Lindau tumor suppressor (VHL) signaling axis. Haase group members take advantage of powerful cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study oxygen and mitochondrial metabolism in kidney, urologic and other diseases. Click on links for information about career opportunities in the Haase lab and recent publications.

Journal Articles

Haase VH, Chertow GM, Block GA, Pergola PE, deGoma EM, Khawaja Z, Sharma A, Maroni BJ, McCullough PA. Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents. Nephrol. Dial. Transplant [print-electronic]. 2018 Apr 4/16/2018; PMID: 29672740, PII: 4973359, DOI: 10.1093/ndt/gfy055, ISSN: 1460-2385.

Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH. Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec; 92(6): 1370-83. PMID: 28847650, PII: S0085-2538(17)30475-1, DOI: 10.1016/j.kint.2017.06.015, ISSN: 1523-1755. See editorial comment in the same issue of Kidney International on page 1314.

Haase VH. HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism. Hemodial Int. 2017 Jun; 21 Suppl 1: S110-S124. PMID: 28449418, DOI: 10.1111/hdi.12567, ISSN: 1542-4758.

Stenvinkel P, Haase VH. Inflamed fat and mitochondrial dysfunction in end-stage renal disease links to hypoxia-could curcumin be of benefit? [editorial]. Nephrol. Dial. Transplant. 2017 Jun 6/1/2017; 32(6): 909-12. PMID: 28460128, PII: 3782571, DOI: 10.1093/ndt/gfx052, ISSN: 1460-2385.

Haase VH. Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies. Exp. Cell Res [print-electronic]. 2017 May 5/5/2017; PMID: 28483447, PII: S0014-4827(17)30268-9, DOI: 10.1016/j.yexcr.2017.05.004, ISSN: 1090-2422.

Haase VH. Oxygen sensors as therapeutic targets in kidney disease. Nephrol. Ther. 2017 Apr; 13 Suppl 1: S29-S34. PMID: 28577740, PII: S1769-7255(17)30039-1, DOI: 10.1016/j.nephro.2017.01.015, ISSN: 1872-9177.

Urrutia AA, Afzal A, Nelson J, Davidoff O, Gross KW, Haase VH. Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytesBlood. 2016 Nov 11/24/2016; 128(21): 2550-60. PMID: 27683416, PII: blood-2016-05-713545, DOI: 10.1182/blood-2016-05-713545, ISSN: 1528-0020. See associated commentary in the same issue of Blood: “Pericytes: new EPO-producing cells in the brain”.

Pergola PE, Spinowitz BS, Hartman CS, Maroni BJ, Haase VH. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney diseaseKidney Int [print-electronic]. 2016 Nov; 90(5): 1115-22. PMID: 27650732, PII: S0085-2538(16)30357-X, DOI: 10.1016/j.kint.2016.07.019, ISSN: 1523-1755.

Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response systemNature [print-electronic]. 2016 Aug 8/8/2016; PMID: 27501247, PII: nature19334, DOI: 10.1038/nature19334, ISSN: 1476-4687.

Kapitsinou PP, Rajendran G, Astleford L, Michael M, Schonfeld MP, Fields T, Shay S, French JL, West J, Haase VH. The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in MiceMol Cell Biol [electronic-print]. 2016 May 5/15/2016; 36(10): 1584-94. PMID: 26976644, PII: MCB.01055-15, DOI: 10.1128/MCB.01055-15, ISSN: 1098-5549.

Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietinJ Clin Invest [print-electronic]. 2016 May 5/2/2016; 126(5): 1926-38. PMID: 27088801, PII: 83551, DOI: 10.1172/JCI83551, ISSN: 1558-8238.

Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O’Connor PM, Haase VH. Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietinJ Clin Invest [print-electronic]. 2016 Apr 4/1/2016; 126(4): 1425-37. PMID: 26927670, PMCID: PMC4811147, PII: 74997, DOI: 10.1172/JCI74997, ISSN: 1558-8238.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertensionAm J Physiol Lung Cell Mol Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.

Kapitsinou PP, Haase VH. Molecular mechanisms of ischemic preconditioning in the kidneyAm J Physiol Renal Physiol [print-electronic]. 2015 Nov 11/15/2015; 309(10): F821-34. PMID: 26311114, PII: ajprenal.00224.2015, DOI: 10.1152/ajprenal.00224.2015, ISSN: 1522-1466.

Haase VH. Inflammation and hypoxia in the kidney: friends or foes?Kidney Int. 2015 Aug; 88(2): 213-5. PMID: 26230196, PMCID: PMC4534718, PII: ki201589, DOI: 10.1038/ki.2015.89, ISSN: 1523-1755.

Koury MJ, Haase VH. Anaemia in kidney disease: harnessing hypoxia responses for therapyNat Rev Nephrol [print-electronic]. 2015 Jul; 11(7): 394-410. PMID: 26055355, PMCID: PMC4497972, PII: nrneph.2015.82, DOI: 10.1038/nrneph.2015.82, ISSN: 1759-507X.

Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injuryAm J Physiol Renal Physiol [print-electronic]. 2015 Jun 6/15/2015; 308(12): F1452-62. PMID: 25925251, PMCID: PMC4469889, PII: ajprenal.00066.2015, DOI: 10.1152/ajprenal.00066.2015, ISSN: 1522-1466.

Haase VH. A breath of fresh air for diabetic nephropathy [editorial]J Am Soc Nephrol [print-electronic]. 2015 Feb; 26(2): 239-41. PMID: 25183808, PMCID: PMC4310668, PII: ASN.2014080754, DOI: 10.1681/ASN.2014080754, ISSN: 1533-3450.

Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injuryJ Clin Invest [print-electronic]. 2014 Jun; 124(6): 2396-409. PMID: 24789906, PMCID: PMC4092875, PII: 69073, DOI: 10.1172/JCI69073, ISSN: 1558-8238.

Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathyJ. Am Soc Nephrol [print-electronic]. 2014 Mar; 25(3): 547-63. PMID: 24262796, PMCID: PMC3935577, PII: ASN.2012101014, DOI: 10.1681/ASN.2012101014, ISSN: 1533-3450.

Haase VH. Mechanisms of hypoxia responses in renal tissueJ Am Soc Nephrol [print-electronic]. 2013 Mar; 24(4): 537-41. PMID: 23334390, PII: ASN.2012080855, DOI: 10.1681/ASN.2012080855, ISSN: 1533-3450.

Haase VH. Regulation of erythropoiesis by hypoxia-inducible factorsBlood Rev [print-electronic]. 2013 Jan; 27(1): 41-53. PMID: 23291219, PMCID: PMC3731139, PII: S0268-960X(12)00084-7, DOI: 10.1016/j.blre.2012.12.003, ISSN: 1532-1681.

Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Celeste Simon M, Giordano FJ, Yun Z. Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophyJ Am Heart Assoc. 2013; 2(6): e000548. PMID: 24326162, PMCID: PMC3886757, PII: jah3381, DOI: 10.1161/JAHA.113.000548, ISSN: 2047-9980.

Liu Q, Davidoff O, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesisJ. Clin. Invest [print-electronic]. 2012 Dec; 122(12): 4635-44. PMID: 23114598, PMCID: PMC3533545, PII: 63924, DOI: 10.1172/JCI63924, ISSN: 1558-8238.

Park SW, Kim M, Kim JY, Brown KM, Haase VH, D’Agati VD, Lee HT. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemiaKidney Int [print-electronic]. 2012 Oct; 82(8): 878-91. PMID: 22695326, PMCID: PMC3443517, PII: ki2012224, DOI: 10.1038/ki.2012.224, ISSN: 1523-1755.

Kobayashi H, Gilbert V, Liu Q, Kapitsinou PP, Unger TL, Rha J, Rivella S, Schlöndorff D, Haase VH. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injuryJ. Immunol [print-electronic]. 2012 May 5/15/2012; 188(10): 5106-15. PMID: 22490864, PMCID: PMC3345098, PII: jimmunol.1103377, DOI: 10.4049/jimmunol.1103377, ISSN: 1550-6606.

Haase VH. Renal cancer: oxygen meets metabolismExp. Cell Res [print-electronic]. 2012 May 5/15/2012; 318(9): 1057-67. PMID: 22406000, PMCID: PMC3334413, PII: S0014-4827(12)00102-4, DOI: 10.1016/j.yexcr.2012.02.026, ISSN: 1090-2422.

Kapitsinou PP, Jaffe J, Michael M, Swan CE, Duffy KJ, Erickson-Miller CL, Haase VH. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injuryAm. J. Physiol. Renal Physiol [print-electronic]. 2012 May 5/1/2012; 302(9): F1172-9. PMID: 22262480, PMCID: PMC3362175, PII: ajprenal.00667.2011, DOI: 10.1152/ajprenal.00667.2011, ISSN: 1522-1466.

Haase VH. Hypoxia-inducible factor signaling in the development of kidney fibrosisFibrogenesis Tissue Repair. 2012; 5(Suppl 1): S16. PMID: 23259746, PMCID: PMC3368791, PII: 1755-1536-5-S1-S16, DOI: 10.1186/1755-1536-5-S1-S16, ISSN: 1755-1536.

Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressureCell Metab. 2011 Apr 4/6/2011; 13(4): 469-75. PMID: 21459331, PMCID: PMC3070917, PII: S1550-4131(11)00088-X, DOI: 10.1016/j.cmet.2011.03.001, ISSN: 1932-7420.

Haase VH. Angiotensin II: breathtaking in the renal medullaKidney Int. 2011 Feb; 79(3): 269-71. PMID: 21228800, PMCID: PMC3621768, PII: ki2010434, DOI: 10.1038/ki.2010.434, ISSN: 1523-1755.

Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humansJ. Clin. Invest [print-electronic]. 2010 Nov; 120(11): 4040-54. PMID: 20978353, PMCID: PMC2964979, PII: 43025, DOI: 10.1172/JCI43025, ISSN: 1558-8238.

Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemiaBlood [print-electronic]. 2010 Oct 10/21/2010; 116(16): 3039-48. PMID: 20628150, PMCID: PMC2974609, PII: blood-2010-02-270322, DOI: 10.1182/blood-2010-02-270322, ISSN: 1528-0020.

Hao CM, Haase VH. Sirtuins and their relevance to the kidneyJ. Am. Soc. Nephrol [print-electronic]. 2010 Oct; 21(10): 1620-7. PMID: 20595677, PMCID: PMC4527176, PII: ASN.2010010046, DOI: 10.1681/ASN.2010010046, ISSN: 1533-3450.

Kapitsinou PP, Haase VH. HO-1 in control of a self-eating kidney [editorial]J. Am. Soc. Nephrol [print-electronic]. 2010 Oct; 21(10): 1600-2. PMID: 20829407, PMCID: PMC4530623, PII: ASN.2010080876, DOI: 10.1681/ASN.2010080876, ISSN: 1533-3450.

Welford SM, Dorie MJ, Li X, Haase VH, Giaccia AJ. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stressMol. Cell. Biol [print-electronic]. 2010 Oct; 30(19): 4595-603. PMID: 20679489, PMCID: PMC2950534, PII: MCB.01618-09, DOI: 10.1128/MCB.01618-09, ISSN: 1098-5549.

Weidemann A, Krohne TU, Aguilar E, Kurihara T, Takeda N, Dorrell MI, Simon MC, Haase VH, Friedlander M, Johnson RS. Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retinaGlia. 2010 Aug; 58(10): 1177-85. PMID: 20544853, PMCID: PMC2993327, DOI: 10.1002/glia.20997, ISSN: 1098-1136.

Haase VH. The sweet side of HIFKidney Int. 2010 Jul; 78(1): 10-3. PMID: 20551925, PMCID: PMC3789845, PII: ki2010112, DOI: 10.1038/ki.2010.112, ISSN: 1523-1755.

Haase VH. Hypoxic regulation of erythropoiesis and iron metabolismAm. J. Physiol. Renal Physiol [print-electronic]. 2010 Jul; 299(1): F1-13. PMID: 20444740, PMCID: PMC2904169, PII: ajprenal.00174.2010, DOI: 10.1152/ajprenal.00174.2010, ISSN: 1522-1466.

Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injuryJ. Am. Soc. Nephrol [print-electronic]. 2010 Jun; 21(6): 955-65. PMID: 20338995, PMCID: PMC2900956, PII: ASN.2009060662, DOI: 10.1681/ASN.2009060662, ISSN: 1533-3450.

Wei Q, Bhatt K, He HZ, Mi QS, Haase VH, Dong Z. Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injuryJ. Am. Soc. Nephrol [print-electronic]. 2010 May; 21(5): 756-61. PMID: 20360310, PMCID: PMC2865746, PII: ASN.2009070718, DOI: 10.1681/ASN.2009070718, ISSN: 1533-3450.

Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS. VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesisAm. J. Pathol [print-electronic]. 2010 May; 176(5): 2269-82. PMID: 20382704, PMCID: PMC2861092, PII: S0002-9440(10)60023-5, DOI: 10.2353/ajpath.2010.090310, ISSN: 1525-2191.

Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axisCarcinogenesis [print-electronic]. 2010 Mar; 31(3): 427-34. PMID: 20042640, PMCID: PMC2832548, PII: bgp326, DOI: 10.1093/carcin/bgp326, ISSN: 1460-2180.

Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS. The glial cell response is an essential component of hypoxia-induced erythropoiesis in miceJ. Clin. Invest [print-electronic]. 2009 Nov; 119(11): 3373-83. PMID: 19809162, PMCID: PMC2769183, PII: 39378, DOI: 10.1172/JCI39378, ISSN: 1558-8238.

Haase VH. Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosisAnn. N. Y. Acad. Sci. 2009 Oct; 1177: 57-65. PMID: 19845607, PMCID: PMC4529330, PII: NYAS5030, DOI: 10.1111/j.1749-6632.2009.05030.x, ISSN: 1749-6632.

Haase VH. Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to diseaseKidney Int [print-electronic]. 2009 Sep; 76(5): 492-9. PMID: 19536078, PMCID: PMC3623274, PII: ki2009222, DOI: 10.1038/ki.2009.222, ISSN: 1523-1755.

Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q, Haase VH. Hypoxia-inducible factor 2 regulates hepatic lipid metabolismMol. Cell. Biol [print-electronic]. 2009 Aug; 29(16): 4527-38. PMID: 19528226, PMCID: PMC2725738, PII: MCB.00200-09, DOI: 10.1128/MCB.00200-09, ISSN: 1098-5549.

Haase VH. The VHL tumor suppressor: master regulator of HIFCurr. Pharm. Des. 2009; 15(33): 3895-903. PMID: 19671042, PMCID: PMC3622710, PII: CPD-Volker H. Haase (Kietzman), ISSN: 1873-4286.

Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, Haase VH, Saito Y. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosisAm. J. Physiol. Renal Physiol [print-electronic]. 2008 Oct; 295(4): F1023-9. PMID: 18667485, PMCID: PMC4250235, PII: 90209.2008, DOI: 10.1152/ajprenal.90209.2008, ISSN: 1931-857X.

Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in miceOncogene [print-electronic]. 2008 Sep 9/11/2008; 27(40): 5354-8. PMID: 18490920, PMCID: PMC2575082, PII: onc2008160, DOI: 10.1038/onc.2008.160, ISSN: 1476-5594.

Haase VH. Hemoglobin in the kidney: breaking with traditional dogma [editorial]J. Am. Soc. Nephrol [print-electronic]. 2008 Aug; 19(8): 1440-1. PMID: 18614770, PII: ASN.2008060594, DOI: 10.1681/ASN.2008060594, ISSN: 1533-3450.

Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascadeGastroenterology [print-electronic]. 2008 Jun; 134(7): 2036-48, 2048.e1. PMID: 18439915, PMCID: PMC2533811, PII: S0016-5085(08)00440-X, DOI: 10.1053/j.gastro.2008.03.009, ISSN: 1528-0012.

Higgins DF, Kimura K, Iwano M, Haase VH. Hypoxia-inducible factor signaling in the development of tissue fibrosisCell Cycle [print-electronic]. 2008 May 5/1/2008; 7(9): 1128-32. PMID: 18418042, PMCID: PMC3784650, PII: 5804, ISSN: 1551-4005.

Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic responseCell. 2008 Apr 4/18/2008; 133(2): 223-34. PMID: 18423195, PMCID: PMC2849644, PII: S0092-8674(08)00289-4, DOI: 10.1016/j.cell.2008.02.038, ISSN: 1097-4172.

Maltzman JS, Haase VH. Low oxygen stimulates the immune systemKidney Int. 2008 Apr; 73(7): 797-9. PMID: 18340350, PMCID: PMC3791324, PII: ki200815, DOI: 10.1038/ki.2008.15, ISSN: 1523-1755.

Peng M, Falk MJ, Haase VH, King R, Polyak E, Selak M, Yudkoff M, Hancock WW, Meade R, Saiki R, Lunceford AL, Clarke CF, Gasser DL. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal diseasePLoS Genet. 2008 Apr; 4(4): e1000061. PMID: 18437205, PMCID: PMC2291193, DOI: 10.1371/journal.pgen.1000061, ISSN: 1553-7404.

Kapitsinou PP, Haase VH. The VHL tumor suppressor and HIF: insights from genetic studies in miceCell Death Differ [print-electronic]. 2008 Apr; 15(4): 650-9. PMID: 18219317, PMCID: PMC3799983, PII: 4402313, DOI: 10.1038/sj.cdd.4402313, ISSN: 1350-9047.

Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transitionJ. Clin. Invest. 2007 Dec; 117(12): 3810-20. PMID: 18037992, PMCID: PMC2082142, DOI: 10.1172/JCI30487, ISSN: 0021-9738.

Brukamp K, Jim B, Moeller MJ, Haase VH. Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular diseaseAm. J. Physiol. Renal Physiol [print-electronic]. 2007 Oct; 293(4): F1397-407. PMID: 17609290, PII: 00133.2007, DOI: 10.1152/ajprenal.00133.2007, ISSN: 1931-857X.

Blouw B, Haase VH, Song H, Bergers G, Johnson RS. Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor geneOncogene [print-electronic]. 2007 Jul 7/5/2007; 26(31): 4531-40. PMID: 17297464, PII: 1210249, DOI: 10.1038/sj.onc.1210249, ISSN: 0950-9232.

Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)J. Clin. Invest. 2007 Jul; 117(7): 1926-32. PMID: 17557118, PMCID: PMC1884690, DOI: 10.1172/JCI31370, ISSN: 0021-9738.

Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal developmentJ. Clin. Invest. 2007 Jun; 117(6): 1616-26. PMID: 17549257, PMCID: PMC1878533, DOI: 10.1172/JCI31581, ISSN: 0021-9738.

Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivoJ. Clin. Invest. 2007 Apr; 117(4): 1068-77. PMID: 17404621, PMCID: PMC1838939, DOI: 10.1172/JCI30117, ISSN: 0021-9738.

Park SK, Haase VH, Johnson RS. Von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphataseInt. J. Oncol. 2007 Feb; 30(2): 341-8. PMID: 17203215, ISSN: 1019-6439.

Ding M, Cui S, Li C, Jothy S, Haase V, Steer BM, Marsden PA, Pippin J, Shankland S, Rastaldi MP, Cohen CD, Kretzler M, Quaggin SE. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in miceNat. Med [print-electronic]. 2006 Sep; 12(9): 1081-7. PMID: 16906157, PII: nm1460, DOI: 10.1038/nm1460, ISSN: 1078-8956.

Haase VH. Hypoxia-inducible factors in the kidneyAm. J. Physiol. Renal Physiol [print-electronic]. 2006 Aug; 291(2): F271-81. PMID: 16554418, PMCID: PMC4232221, PII: 00071.2006, DOI: 10.1152/ajprenal.00071.2006, ISSN: 1931-857X.

Wang J, Biju MP, Wang MH, Haase VH, Dong Z. Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppressionJ. Am. Soc. Nephrol [print-electronic]. 2006 Jul; 17(7): 1875-85. PMID: 16762987, PII: ASN.2005121371, DOI: 10.1681/ASN.2005121371, ISSN: 1046-6673.

Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivoBlood [print-electronic]. 2006 Jul 7/1/2006; 108(1): 123-33. PMID: 16527892, PMCID: PMC1895827, PII: 2005-11-4458, DOI: 10.1182/blood-2005-11-4458, ISSN: 0006-4971.

Tang N, Mack F, Haase VH, Simon MC, Johnson RS. PVHL function is essential for endothelial extracellular matrix depositionMol. Cell. Biol. 2006 Apr; 26(7): 2519-30. PMID: 16537898, PMCID: PMC1430327, PII: 26/7/2519, DOI: 10.1128/MCB.26.7.2519-2530.2006, ISSN: 0270-7306.

Haase VH. The VHL/HIF oxygen-sensing pathway and its relevance to kidney diseaseKidney Int. 2006 Apr; 69(8): 1302-7. PMID: 16531988, PII: 5000221, DOI: 10.1038/, ISSN: 0085-2538.

Rankin EB, Tomaszewski JE, Haase VH. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressorCancer Res. 2006 Mar 3/1/2006; 66(5): 2576-83. PMID: 16510575, PMCID: PMC3514875, PII: 66/5/2576, DOI: 10.1158/0008-5472.CAN-05-3241, ISSN: 0008-5472.

Biju MP, Akai Y, Shrimanker N, Haase VH. Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependentAm. J. Physiol. Renal Physiol [print-electronic]. 2005 Dec; 289(6): F1217-26. PMID: 16048903, PII: 00233.2005, DOI: 10.1152/ajprenal.00233.2005, ISSN: 1931-857X.

Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transductionProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Nov 11/22/2005; 102(47): 17071-6. PMID: 16286658, PMCID: PMC1287984, PII: 0506070102, DOI: 10.1073/pnas.0506070102, ISSN: 0027-8424.

Haase VH. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targetingSemin. Cell Dev. Biol [print-electronic]. 2005 Aug; 16(4-5): 564-74. PMID: 15908240, PMCID: PMC3787877, PII: S1084-9521(05)00052-2, DOI: 10.1016/j.semcdb.2005.03.006, ISSN: 1084-9521.

Mack FA, Patel JH, Biju MP, Haase VH, Simon MC. Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27Mol. Cell. Biol. 2005 Jun; 25(11): 4565-78. PMID: 15899860, PMCID: PMC1140627, PII: 25/11/4565, DOI: 10.1128/MCB.25.11.4565-4578.2005, ISSN: 0270-7306.

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in miceMol. Cell. Biol. 2005 Apr; 25(8): 3163-72. PMID: 15798202, PMCID: PMC1069599, PII: 25/8/3163, DOI: 10.1128/MCB.25.8.3163-3172.2005, ISSN: 0270-7306.

Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxia-inducible factorCell Cycle [print-electronic]. 2005 Feb; 4(2): 256-8. PMID: 15655360, PII: 1407, ISSN: 1551-4005.

Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. Hypoxic induction of Ctgf is directly mediated by Hif-1Am. J. Physiol. Renal Physiol [print-electronic]. 2004 Dec; 287(6): F1223-32. PMID: 15315937, PII: 00245.2004, DOI: 10.1152/ajprenal.00245.2004, ISSN: 1931-857X.

Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitisJ. Clin. Invest. 2004 Oct; 114(8): 1098-106. PMID: 15489957, PMCID: PMC522241, DOI: 10.1172/JCI21086, ISSN: 0021-9738.

Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytesMol. Cell. Biol. 2004 Oct; 24(20): 9038-47. PMID: 15456877, PMCID: PMC517905, PII: 24/20/9038, DOI: 10.1128/MCB.24.20.9038-9047.2004, ISSN: 0270-7306.

Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate developmentDevelopment. 2004 May; 131(10): 2497-508. PMID: 15128677, PII: 131/10/2497, DOI: 10.1242/dev.01138, ISSN: 0950-1991.

Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR. DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transitionKidney Int. 2003 Dec; 64(6): 2079-91. PMID: 14633130, DOI: 10.1046/j.1523-1755.2003.00306.x, ISSN: 0085-2538.

Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alphaMol. Cell. Biol. 2003 Jul; 23(14): 4959-71. PMID: 12832481, PMCID: PMC162224, ISSN: 0270-7306.

Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. HIF-1alpha is essential for myeloid cell-mediated inflammationCell. 2003 Mar 3/7/2003; 112(5): 645-57. PMID: 12628185, PMCID: PMC4480774, PII: S0092867403001545, ISSN: 0092-8674.

Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblastsBlood. 2001 Dec 12/1/2001; 98(12): 3261-73. PMID: 11719363, ISSN: 0006-4971.

Haase VH, Glickman JN, Socolovsky M, Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressorProc. Natl. Acad. Sci. U.S.A. 2001 Feb 2/13/2001; 98(4): 1583-8. PMID: 11171994, PMCID: PMC29300, PII: 98/4/1583, DOI: 10.1073/pnas.98.4.1583, ISSN: 0027-8424.