Book Chapters and Teaching
Changes in tissue oxygen levels occur under pathological conditions and physiologically during development. The laboratory of Professor Volker H. Haase studies hypoxia response pathways and their therapeutic applications in erythropoiesis and iron metabolism, tissue injury and ischemic pre-conditioning, inflammation, kidney development and tumorigenesis.
The lab has largely focused on the hypoxia-inducible factor (HIF) pathway, its regulation by prolyl hydroxylase domain (PHD) oxygen sensors and the von Hippel-Lindau (VHL) tumor suppressor. Haase group members take advantage of cutting-edge mouse genetics, biochemical, metabolomic and single cell approaches to study the PHD/HIF pathway in the setting of acute and chronic kidney disease as well as other conditions. For career opportunities in the laboratory of Volker H. Haase please click here, for recent featured publications from our group please click here.
Brukamp K., Haase V.H.: von Hippel-Lindau Disease, Pheochromocytomas and Hypertension in “Advanced Therapy in Hypertension and Vascular Disease” Townsend RR, Mohler ER. (eds.). BC Decker, 2005.
Haase VH. Oxygen-dependent regulation of erythropoiesis in “Oxidative Stress in Basic Research and Clinical Practice” Miyata T, Eckardt KU, Nangaku M. (eds). Humana/Springer, 2010.
Professor Haase discusses HIF stabilizers in renal anemia
VuMedi Webinar: Therapeutic options for anemia in chronic kidney disease, 03/28/18
(click on image to download slide set)
(click on image to view video)