Project Description

Kidney Int. 2020 Apr;97(4):645-647. doi:10.1016/j.kint.2019.11.036.

Got Glycogen? An Energy Resource in HIF-mediated Prevention of Ischemic Kidney Injury.

Commentary: Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage

Haase VH

Hypoxia-inducible factor activation reprograms glucose metabolism and leads to glycogen accumulation in multiple cell types. In the April of 2020 issue of Kidney International, Ito and colleagues demonstrate that pharmacologic inhibition of hypoxia-inducible factor–prolyl hydroxylase domain oxygen sensors in renal epithelial cells enhances glycogen synthesis and protects from subsequent hypoxia and glucose deprivation. In vivo studies advance the concept that renal glycogen metabolism contributes to cytoprotection afforded by pre-ischemic hypoxia-inducible factor–prolyl hydroxylase domain inhibition.

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link to paper by Ito and colleagues in Kidney International, April 2020